Effect of avocado seed extract on lipid profile and atherogenic index in cyclosporine-treated rats

Hypertension is a global health issue because of its high prevalence and association with increased risk cardiovascular disease. This work evaluated the anti-dyslipidemic potential aqueous extract avocado seed (APE) (50 – 100 mg/kg) in adult male wistar rats. Twenty-five rats were used for this divided into five groups 5 each (n= 5). Group 1 (normal control), group 2 (cyclosporine alone), 3 + mg lisinopril), 4 50 mg/kg b.wt respectively). Treatments lasted 7 days sacrificed by cervical dislocation. Plasma samples from lipid profile analysis such as; total cholesterol, triglyceride, density lipoprotein. The results showed significant (p < 0.05) increase triglyceride (TG), low lipoprotein (LDL), cholesterol (TCH), as well decrease HDL atherogenic index cyclosporine only treated compared normal control group. However, treatment caused TG, LDL, concomitant concentration dose-dependent manner. findings study suggest that has which could be useful management hypertension other diseases arising dyslipidemia.